UPS Airlines Flight 2976 was a scheduled domestic Cargo Flight in the United States from Louisville Airport in Louisville, Kentucky, to Honolulu, Hawaii. On November 4, 2025, the aircraft operating the flight, a 34-year-old McDonnell Douglas MD-11F with manufacturer serial number 48417 and registration N259UP, suffered a separation of its left engine during its takeoff roll. The aircraft crashed shortly after liftoff from the runway, at about 5:13 p.m. local time, into an industrial area near Knopp, Louisville, Kentucky, United States (38°8′50″N 85°44′4″W). The crash killed fourteen people, including all three crew members on board the aircraft, and resulted in 23 injuries. The accident is being investigated by the NTSB.
